deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 4-arm NCT06297603

Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)

A Phase 3, Randomized, Multicenter, Double-Blind Study to Investigate the Efficacy and Safety of Retatrutide Once Weekly Compared With Placebo in Adult Participants With Type 2 Diabetes, Moderate or Severe Renal Impairment With Inadequate Glycemic Control on Basal Insulin With or Without Metformin and/or SGLT2 Inhibitor

Sponsor: Eli Lilly and Company

Updated 20 times since 2024 Last updated: Dec 23, 2025 Started: Mar 15, 2024 Primary completion: Oct 31, 2026 Completion: Nov 30, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Type 2 Diabetes and is currently ongoing. Eli Lilly and Company leads this study, which shows 20 recorded versions since 2024 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – present · 8 months · monthly snapshotActive Not Recruiting

Change History

20 versions recorded
  1. Jan 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  3. Nov 2025 — Dec 2025 [monthly]

    Recruiting PHASE3

  4. Oct 2025 — Nov 2025 [monthly]

    Recruiting PHASE3

  5. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE3

Show 15 earlier versions
  1. Aug 2025 — Sep 2025 [monthly]

    Recruiting PHASE3

  2. Jul 2025 — Aug 2025 [monthly]

    Recruiting PHASE3

  3. Jun 2025 — Jul 2025 [monthly]

    Recruiting PHASE3

  4. May 2025 — Jun 2025 [monthly]

    Recruiting PHASE3

  5. Mar 2025 — May 2025 [monthly]

    Recruiting PHASE3

  6. Feb 2025 — Mar 2025 [monthly]

    Recruiting PHASE3

  7. Jan 2025 — Feb 2025 [monthly]

    Recruiting PHASE3

  8. Nov 2024 — Jan 2025 [monthly]

    Recruiting PHASE3

  9. Oct 2024 — Nov 2024 [monthly]

    Recruiting PHASE3

  10. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE3

  11. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

  12. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE3

  13. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE3

  14. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  15. Apr 2024 — May 2024 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Mar 2024

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Eli Lilly and Company
Data source: Eli Lilly and Company

For direct contact, visit the study record on ClinicalTrials.gov .