deltatrials
Recruiting PHASE2 INTERVENTIONAL 2-arm NCT06319274

Infusion of Prostacyclin vs Placebo for 72-hours in Mechanically Ventilated Patients With Acute Respiratory Failure (COMBAT-ARF)

Efficacy and Safety of 72-hour Infusion of Prostacyclin (1 ng/kg/Min) in Mechanically Ventilated Patients With Infectious Pulmonary Endotheliopathy - a Multicenter Randomized, Placebo-controlled, Blinded, Investigator-initiated Trial

Sponsor: Pär Johansson

Updated 7 times since 2024 Last updated: Aug 18, 2025 Started: Apr 15, 2024 Primary completion: Sep 30, 2027 Completion: Sep 30, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT06319274, this PHASE2 trial focuses on Acute Respiratory Failure and Endothelial Dysfunction and remains actively recruiting participants. Sponsored by Pär Johansson, it has been updated 7 times since 2024, reflecting limited change activity. This study is part of the global effort to build evidence for infectious disease interventions.

Status Flow

~Apr 2024 – ~Jun 2024 · 2 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshotRecruiting~Dec 2024 – ~Jul 2025 · 7 months · monthly snapshotRecruiting~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshotRecruiting

Change History

7 versions recorded
  1. Sep 2025 — Present [monthly]

    Recruiting PHASE2

  2. Jul 2025 — Sep 2025 [monthly]

    Recruiting PHASE2

  3. Dec 2024 — Jul 2025 [monthly]

    Recruiting PHASE2

  4. Sep 2024 — Dec 2024 [monthly]

    Recruiting PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

Show 2 earlier versions
  1. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  2. Apr 2024 — Jun 2024 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Pär Johansson
Data source: Rigshospitalet, Denmark

For direct contact, visit the study record on ClinicalTrials.gov .