Active Not Recruiting EARLY_PHASE1 INTERVENTIONAL 1-arm NCT06366672

Evaluating the Human Immune Response to the JYNNEOS Vaccine

Evaluating the Durability of the Human Immune Response to the JYNNEOS Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) Vaccine

Sponsor: Washington University School of Medicine

Conditions Vaccinia Virus Diseases

Interventions Bone marrow aspiration JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) suspension for subcutaneous injection Phlebotomy Research bronchoscopy Skin punch biopsy

Updated 6 times since 2024 Last updated: Oct 14, 2025 Started: Jun 10, 2024 Primary completion: Sep 30, 2026 Completion: Dec 31, 2026

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This EARLY_PHASE1 trial investigates Vaccinia and Virus Diseases and is currently ongoing. Washington University School of Medicine leads this study, which shows 6 recorded versions since 2024 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

6 versions recorded

Nov 2025 — Present [monthly]

Active Not Recruiting EARLY_PHASE1

Status: Recruiting → Active Not Recruiting
Sep 2025 — Nov 2025 [monthly]

Recruiting EARLY_PHASE1
Aug 2025 — Sep 2025 [monthly]

Recruiting EARLY_PHASE1
Sep 2024 — Aug 2025 [monthly]

Recruiting EARLY_PHASE1
Jul 2024 — Sep 2024 [monthly]

Recruiting EARLY_PHASE1

Status: Not Yet Recruiting → Recruiting

▶ Show 1 earlier version

May 2024 — Jul 2024 [monthly]

Not Yet Recruiting EARLY_PHASE1

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Washington University School of Medicine

Data source: Washington University School of Medicine

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• St Louis, United States