deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT06396065

Phase III Study of AK112 for NSCLC Patients

A Randomized, Double-blind, Multi-center, Phase III Study of AK112 or Placebo Combined With Pemetrexed and Carboplatin in Patients With EGFR-mutant Locally Advanced or Metastatic Non-squamous NSCLC Who Have Failed to EGFR-TKI Treatment

Sponsor: Akeso

Updated 8 times since 2024 Last updated: Feb 27, 2026 Started: May 4, 2023 Primary completion: Apr 12, 2025 Completion: Dec 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT06396065, this PHASE3 trial focuses on Non-Squamous Non-small Cell Lung Cancer and remains ongoing. Sponsored by Akeso, it has been updated 8 times since 2023, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Sep 2025 · 10 months · monthly snapshotActive Not Recruiting~Sep 2025 – ~Mar 2026 · 6 months · monthly snapshotActive Not Recruiting~Mar 2026 – present · 5 months · monthly snapshotActive Not Recruiting

Change History

8 versions recorded
  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Sep 2025 — Mar 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Nov 2024 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  5. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE3

Show 3 earlier versions
  1. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

  2. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE3

  3. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE3

    First recorded

May 2023

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Akeso
  • Summit Therapeutics
Data source: Summit Therapeutics

For direct contact, visit the study record on ClinicalTrials.gov .