Completed EARLY_PHASE1 INTERVENTIONAL 1-arm NCT06413095

PBI-MST-01 (NCT04541108) Substudy MSD-03: Intratumoral Microdosing of Pembrolizumab Alone and With MK-0482 or MK-4830 in HNSCC or STS

Pembrolizumab Alone and in Combination(s) With MK-0482 and MK-4830 Via Intratumoral Injection in Patients With Head and Neck Squamous Cell Carcinoma or Soft Tissue Sarcoma Prior to Planned Surgical Intervention

Sponsor: Merck Sharp & Dohme LLC

Conditions Head and Neck Squamous Cell Carcinoma Soft Tissue Sarcoma

Interventions MK-0482 + Pembrolizumab MK-4830 + Pembrolizumab Pembrolizumab

Updated 4 times since 2024 Last updated: May 8, 2024 Started: Jun 1, 2022 Primary completion: Jun 22, 2023 Completion: Jun 22, 2023

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A EARLY_PHASE1 clinical study on Head and Neck Squamous Cell Carcinoma and Soft Tissue Sarcoma, this trial is completed. The trial is conducted by Merck Sharp & Dohme LLC and has accumulated 4 data snapshots since 2022. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

4 versions recorded

Sep 2025 — Present [monthly]

Completed EARLY_PHASE1
Sep 2024 — Sep 2025 [monthly]

Completed EARLY_PHASE1
Jul 2024 — Sep 2024 [monthly]

Completed EARLY_PHASE1
Jun 2024 — Jul 2024 [monthly]

Completed EARLY_PHASE1

First recorded

Jun 2022

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Merck Sharp & Dohme LLC
Presage Biosciences

Data source: Presage Biosciences

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Atlanta, United States , Chapel Hill, United States , Charleston, United States , Cincinnati, United States , Houston, United States , Philadelphia, United States , Portland, United States , Sacramento, United States , Seattle, United States , Shreveport, United States and 1 more location