Recruiting PHASE4 INTERVENTIONAL 1-arm NCT06666621

Endogenous Opioid Response to Injections (AEOUI2)

Antagonism of Endogenous Opioids: Use in Interpretation of Injections

Sponsor: International Pain and Spine Intervention Society

Conditions Low Back Pain Zygapophyseal Joint Arthritis

Interventions Naloxone infusion Normal saline infusion

Updated 2 times since 2024 Last updated: May 14, 2025 Started: Aug 22, 2024 Primary completion: Oct 31, 2025 Completion: Feb 28, 2026

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Low Back Pain and Zygapophyseal Joint Arthritis and is currently actively recruiting participants. International Pain and Spine Intervention Society leads this study, which shows 2 recorded versions since 2024 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

2 versions recorded

Jun 2025 — Present [monthly]

Recruiting PHASE4

Status: Not Yet Recruiting → Recruiting
Nov 2024 — Jun 2025 [monthly]

Not Yet Recruiting PHASE4

First recorded

Aug 2024

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

International Pain and Spine Intervention Society
Middle Tennessee Research Institute

Data source: Middle Tennessee Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Nashville, United States