deltatrials
Recruiting PHASE1 INTERVENTIONAL 9-arm NCT06789172

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors (INVOKE)

A Phase 1, Open-label, Multicenter, Dose-escalation and Cohort Expansion Study of OKN4395, a Triple Antagonist of EP2, EP4, and DP1 Prostanoid Receptors, as Monotherapy and in Combination With Pembrolizumab, in Patients With Advanced Solid Tumors

Sponsor: Epkin

Conditions Colorectal Cancer (CRC) Dedifferentiated Liposarcoma HNSCC Head and Neck Squamous Cell Carcinoma Myxofibrosarcoma (MFS) NSCLC Non Small Cell Lung Cancer Pancreatic Adenocarcinoma Sarcoma Solid Tumours Solitary Fibrous Tumors Undifferentiated Pleomorphic Sarcoma (UPS)
Interventions Fasting Fed H2 Receptor Antagonist OKN4395 Pembrolizumab
Updated 7 times since 2025 Last updated: Aug 29, 2025 Started: Jan 23, 2025 Primary completion: Jul 31, 2028 Completion: Sep 30, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Colorectal Cancer (CRC) and Dedifferentiated Liposarcoma, this trial is actively recruiting participants. The trial is conducted by Epkin and has accumulated 7 data snapshots since 2025. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jul 2025 · 2 months · monthly snapshotRecruiting~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Oct 2025 · 2 months · monthly snapshotRecruiting~Oct 2025 – present · 10 months · monthly snapshotRecruiting

Change History

7 versions recorded

  1. Oct 2025 — Present [monthly]

    Recruiting PHASE1

  2. Aug 2025 — Oct 2025 [monthly]

    Recruiting PHASE1

  3. Jul 2025 — Aug 2025 [monthly]

    Recruiting PHASE1

  4. May 2025 — Jul 2025 [monthly]

    Recruiting PHASE1

  5. Apr 2025 — May 2025 [monthly]

    Recruiting PHASE1

▶ Show 2 earlier versions

  1. Mar 2025 — Apr 2025 [monthly]

    Recruiting PHASE1

  2. Feb 2025 — Mar 2025 [monthly]

    Recruiting PHASE1

    First recorded

Jan 2025

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Epkin
  • Precision For Medicine
Data source: Epkin

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations