deltatrials
Recruiting PHASE1 INTERVENTIONAL 3-arm NCT06796686

Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in Overall Good Health

A Phase 1 Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in Overall Good Health

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Conditions HIV
Updated 4 times since 2025 Last updated: Sep 23, 2025 Started: Mar 17, 2025 Primary completion: Jan 15, 2027 Completion: Jan 15, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates HIV and is currently actively recruiting participants. National Institute of Allergy and Infectious Diseases (NIAID) leads this study, which shows 4 recorded versions since 2025 — indicating limited longitudinal coverage. Longitudinal tracking of infectious disease trials helps identify durability of treatment effects.

Status Flow

~Feb 2025 – ~Apr 2025 · 59 days · monthly snapshotNot Yet Recruiting~Apr 2025 – ~Jul 2025 · 3 months · monthly snapshotRecruiting~Jul 2025 – ~Oct 2025 · 3 months · monthly snapshotRecruiting~Oct 2025 – present · 9 months · monthly snapshotRecruiting

Change History

4 versions recorded
  1. Oct 2025 — Present [monthly]

    Recruiting PHASE1

  2. Jul 2025 — Oct 2025 [monthly]

    Recruiting PHASE1

  3. Apr 2025 — Jul 2025 [monthly]

    Recruiting PHASE1

    Status: Not Yet RecruitingRecruiting

  4. Feb 2025 — Apr 2025 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Institute of Allergy and Infectious Diseases (NIAID)
Data source: National Institute of Allergy and Infectious Diseases (NIAID)

For direct contact, visit the study record on ClinicalTrials.gov .