Recruiting PHASE1/PHASE2 INTERVENTIONAL 7-arm NCT06810544

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

A Phase 1/2, Multicenter, Open-Label Study to Evaluate the Safety, Tolerability, and Preliminary Antitumor Activity of TNG456 Monotherapy and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

Sponsor: Eli Lilly and Company

Conditions Brain Tumor Glioma Glioblastoma Multiforme Glioma, Malignant Lung Cancer Non Small Cell Lung Cancer Non-Small Cell Adenocarcinoma Solid Tumor

Interventions TNG456 abemaciclib

Updated 8 times since 2025 Last updated: Jan 30, 2026 Started: Mar 24, 2025 Primary completion: Mar 31, 2027 Completion: Sep 30, 2027

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1/PHASE2 clinical study on Brain Tumor and Glioma Glioblastoma Multiforme, this trial is actively recruiting participants. The trial is conducted by Eli Lilly and Company and has accumulated 8 data snapshots since 2025. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

8 versions recorded

Feb 2026 — Present [monthly]

Recruiting PHASE1/PHASE2
Dec 2025 — Feb 2026 [monthly]

Recruiting PHASE1/PHASE2
Sep 2025 — Dec 2025 [monthly]

Recruiting PHASE1/PHASE2
Aug 2025 — Sep 2025 [monthly]

Recruiting PHASE1/PHASE2
Jul 2025 — Aug 2025 [monthly]

Recruiting PHASE1/PHASE2

▶ Show 3 earlier versions

May 2025 — Jul 2025 [monthly]

Recruiting PHASE1/PHASE2
Apr 2025 — May 2025 [monthly]

Recruiting PHASE1/PHASE2

Status: Not Yet Recruiting → Recruiting
Mar 2025 — Apr 2025 [monthly]

Not Yet Recruiting PHASE1/PHASE2

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Eli Lilly and Company
Tango Therapeutics, Inc.

Data source: Tango Therapeutics, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Boston, United States , Chicago, United States , Columbus, United States , Fairfax, United States , Houston, United States , Irvine, United States , Jacksonville, United States , New York, United States , Rochester, United States , Salt Lake City, United States and 2 more locations