Recruiting PHASE4 INTERVENTIONAL 2-arm NCT06853431

Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia

Sponsor: Second Affiliated Hospital of Wenzhou Medical University

Conditions Children Dexmedetomidine ED50 ED95 Esketamine Preoperative Anxiety Preoperative Sedation Preoperative Sedation of Children

Interventions Esketamine dexmedetomidine

Updated 3 times since 2025 Last updated: Nov 24, 2025 Started: Mar 1, 2025 Primary completion: Nov 30, 2025 Completion: Nov 30, 2025

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Children and Dexmedetomidine and is currently actively recruiting participants. Second Affiliated Hospital of Wenzhou Medical University leads this study, which shows 3 recorded versions since 2025 — indicating limited longitudinal coverage. This study adds to the longitudinal dataset for psychiatric treatment development.

Status Flow

Change History

3 versions recorded

Jan 2026 — Present [monthly]

Recruiting PHASE4
Oct 2025 — Jan 2026 [monthly]

Recruiting PHASE4
Apr 2025 — Oct 2025 [monthly]

Recruiting PHASE4

First recorded

Mar 2025

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Second Affiliated Hospital of Wenzhou Medical University

Data source: Second Affiliated Hospital of Wenzhou Medical University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Wenzhou, China