Recruiting PHASE3 INTERVENTIONAL 2-arm NCT06876714

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

ShortStop-HER2: Shortened Duration of Adjuvant Therapy in Patients With Early-Stage HER2+ Breast Cancer Who Achieve pCR After Neoadjuvant Chemotherapy With HER2 Blockade

Sponsor: Alliance for Clinical Trials in Oncology

Conditions Anatomic Stage I Breast Cancer AJCC v8 Anatomic Stage II Breast Cancer AJCC v8 Early Stage Breast Carcinoma

Interventions Biospecimen Collection Echocardiography Magnetic Resonance Imaging Mammography Multigated Acquisition Scan Pertuzumab Questionnaire Administration Trastuzumab (Herceptin) Ultrasound

Updated 6 times since 2025 Last updated: Feb 3, 2026 Started: Sep 17, 2025 Primary completion: Mar 13, 2028 Completion: Mar 13, 2037

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Anatomic Stage I Breast Cancer AJCC v8 and Anatomic Stage II Breast Cancer AJCC v8 and is currently actively recruiting participants. Alliance for Clinical Trials in Oncology leads this study, which shows 6 recorded versions since 2025 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

Change History

6 versions recorded

Feb 2026 — Present [monthly]

Recruiting PHASE3
Jan 2026 — Feb 2026 [monthly]

Recruiting PHASE3
Dec 2025 — Jan 2026 [monthly]

Recruiting PHASE3
Nov 2025 — Dec 2025 [monthly]

Recruiting PHASE3

Status: Not Yet Recruiting → Recruiting
Oct 2025 — Nov 2025 [monthly]

Not Yet Recruiting PHASE3

▶ Show 1 earlier version

Apr 2025 — Oct 2025 [monthly]

Not Yet Recruiting PHASE3

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Data source: Alliance for Clinical Trials in Oncology

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aberdeen, United States , Albuquerque, United States , Alliance, United States , Alton, United States , Ames, United States , Anaconda, United States , Ankeny, United States , Ann Arbor, United States , Antigo, United States , Arroyo Grande, United States and 352 more locations