deltatrials
Recruiting NA INTERVENTIONAL 2-arm NCT06960564

The Effect of Hyaluronic Acid Injection on TNF-Alpha and IL-1β in Knee Osteoarthritis

Investigation of the Effect of Hyaluronic Acid Injection on Tnf-Alpha and IL-1beta at DNA-Protein Level in Knee Osteoarthritis Patients and Comparison With Clinical Parameters: A Randomised Controlled Trial

Sponsor: Istanbul University

Conditions Hyaluronic Acid Knee Osteoarthritis
Interventions Hyaluronic Acid injections Saline -- placebo comparator
Updated 4 times since 2025 Last updated: Jan 8, 2026 Started: May 12, 2025 Primary completion: Jan 30, 2026 Completion: Mar 29, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates Hyaluronic Acid and Knee Osteoarthritis and is currently actively recruiting participants. Istanbul University leads this study, which shows 4 recorded versions since 2025 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshotRecruiting~Sep 2025 – ~Feb 2026 · 5 months · monthly snapshotRecruiting~Feb 2026 – present · 6 months · monthly snapshotRecruiting

Change History

4 versions recorded

  1. Feb 2026 — Present [monthly]

    Recruiting NA

  2. Sep 2025 — Feb 2026 [monthly]

    Recruiting NA

  3. Jul 2025 — Sep 2025 [monthly]

    Recruiting NA

    Status: Not Yet Recruiting → Recruiting

  4. Jun 2025 — Jul 2025 [monthly]

    Not Yet Recruiting NA

    First recorded

May 2025

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Istanbul University
  • Istanbul University Research Fund
Data source: Istanbul University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations