Recruiting PHASE1/PHASE2 INTERVENTIONAL 4-arm NCT07038343

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

A Phase 1/2, First-in-human Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors

Sponsor: Avenzo Therapeutics, Inc.

Conditions Epithelial Tumor Locally Advanced Lung Cancers Metastatic Solid Tumors Solid Tumor Cancer

Interventions AVZO-1418 Combination Agent 1 Combination Agent 2

Updated 4 times since 2025 Last updated: Feb 18, 2026 Started: Jun 4, 2025 Primary completion: Jun 30, 2030 Completion: Dec 31, 2030

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1/PHASE2 clinical study on Epithelial Tumor and Locally Advanced, this trial is actively recruiting participants. The trial is conducted by Avenzo Therapeutics, Inc. and has accumulated 4 data snapshots since 2025. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

4 versions recorded

Feb 2026 — Present [monthly]

Recruiting PHASE1/PHASE2
Jan 2026 — Feb 2026 [monthly]

Recruiting PHASE1/PHASE2
Oct 2025 — Jan 2026 [monthly]

Recruiting PHASE1/PHASE2
Jul 2025 — Oct 2025 [monthly]

Recruiting PHASE1/PHASE2

First recorded

Jun 2025

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Avenzo Therapeutics, Inc.

Data source: Avenzo Therapeutics, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Atlanta, United States , Boston, United States , Dallas, United States , Denver, United States , Fairfax, United States , Gilbert, United States , Houston, United States , Los Angeles, United States , New Haven, United States , Orlando, United States and 6 more locations