deltatrials
Recruiting PHASE4 INTERVENTIONAL 1-arm NCT07053345

A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant Depression

An Interventional, Open-label, Single Arm, Multicenter Study to Evaluate the Efficacy and Safety of Esketamine Nasal Spray in Korean Participants With Treatment-Resistant Depression(TRD)

Sponsor: Janssen Korea, Ltd., Korea

Conditions Depressive Disorder, Treatment-Resistant
Interventions Esketamine 56 mg Esketamine 84 mg
Updated 8 times since 2025 Last updated: Mar 12, 2026 Started: Jun 9, 2025 Primary completion: Jun 25, 2027 Completion: Jun 25, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Depressive Disorder, Treatment-Resistant and is currently actively recruiting participants. Janssen Korea, Ltd., Korea leads this study, which shows 8 recorded versions since 2025 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshotRecruiting~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshotRecruiting~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshotRecruiting~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshotRecruiting~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshotRecruiting~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshotRecruiting~Feb 2026 – ~Mar 2026 · 28 days · monthly snapshotRecruiting~Mar 2026 – present · 4 months · monthly snapshotRecruiting

Change History

8 versions recorded

  1. Mar 2026 — Present [monthly]

    Recruiting PHASE4

  2. Feb 2026 — Mar 2026 [monthly]

    Recruiting PHASE4

  3. Jan 2026 — Feb 2026 [monthly]

    Recruiting PHASE4

  4. Dec 2025 — Jan 2026 [monthly]

    Recruiting PHASE4

  5. Nov 2025 — Dec 2025 [monthly]

    Recruiting PHASE4

▶ Show 3 earlier versions

  1. Oct 2025 — Nov 2025 [monthly]

    Recruiting PHASE4

  2. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE4

  3. Aug 2025 — Sep 2025 [monthly]

    Recruiting PHASE4

    First recorded

Jun 2025

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Korea, Ltd., Korea
Data source: Janssen Korea, Ltd., Korea

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations