deltatrials
Completed NA INTERVENTIONAL 2-arm NCT07155642

Yoga in Multiple Sclerosis Patients

Effects of Yoga and Conventional Physiotherapy Programs on Fatigue, Balance, Walking and Quality of Life in Multiple Sclerosis Patients.

Sponsor: Istanbul Rumeli University

Updated 2 times since 2025 Last updated: Sep 1, 2025 Started: Mar 4, 2019 Primary completion: Apr 20, 2019 Completion: Jun 7, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates Multiple Sclerosis and is currently completed. Istanbul Rumeli University leads this study, which shows 2 recorded versions since 2019 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Study Description(click to expand)

Intervention Protocol Yoga Program The yoga intervention will be implemented in small groups of up to five participants, three times per week for a duration of eight weeks. Sessions will be led by a physiotherapist experienced in working with multiple sclerosis (MS) patients and certified in yoga practice. Each session will last 60 minutes and will consist of four structured components: Centering/Meditation (5-10 minutes): Participants will perform breath-focused meditation in a comfortable seated position, using cushions if required. The duration will begin at 5 minutes during the first week and will gradually increase to 8-10 minutes by the third week. Participants will be instructed to count their breaths up to ten, restarting from one if their focus drifts. Yin and Yang Yoga Poses (40 minutes): This segment will combine Yin poses (passive, long-held postures targeting connective tissues) and Yang poses (active, dynamic postures). Yin poses: Held for 2-3 minutes. Yang poses: Will include Bridge, Plank, Low Lunge, Crescent Lunge, Cat-Cow, Downward-Facing Dog, and Chair Pose. These will be held for 10-30 seconds and repeated at least three times. Rest periods of 30-60 seconds in Child's Pose will be incorporated between sequences. Postures will be adapted according to individual needs and...

Intervention Protocol Yoga Program

The yoga intervention will be implemented in small groups of up to five participants, three times per week for a duration of eight weeks. Sessions will be led by a physiotherapist experienced in working with multiple sclerosis (MS) patients and certified in yoga practice. Each session will last 60 minutes and will consist of four structured components:

Centering/Meditation (5-10 minutes):

Participants will perform breath-focused meditation in a comfortable seated position, using cushions if required. The duration will begin at 5 minutes during the first week and will gradually increase to 8-10 minutes by the third week. Participants will be instructed to count their breaths up to ten, restarting from one if their focus drifts.

Yin and Yang Yoga Poses (40 minutes):

This segment will combine Yin poses (passive, long-held postures targeting connective tissues) and Yang poses (active, dynamic postures).

Yin poses: Held for 2-3 minutes.

Yang poses: Will include Bridge, Plank, Low Lunge, Crescent Lunge, Cat-Cow, Downward-Facing Dog, and Chair Pose. These will be held for 10-30 seconds and repeated at least three times.

Rest periods of 30-60 seconds in Child's Pose will be incorporated between sequences. Postures will be adapted according to individual needs and physical capacities, applying the "soft edge" principle to avoid discomfort. Props such as blocks will be used as needed. Both verbal and tactile corrections will be provided.

Breathing Exercises (Pranayama) (1-2 minutes):

Alternating Nostril Breathing (Nadi Shodhana) will be practiced to balance the effects of Yin and Yang postures.

Deep Relaxation (Savasana) (10 minutes):

Sessions will conclude with Savasana, in which participants will lie supine for 10 minutes with arms relaxed at the sides and palms facing upward, maintaining complete stillness and relaxation.

During yoga sessions, the room temperature will be maintained at 23-26°C, and soft, relaxing music will be played.

Physiotherapy Program

Participants assigned to the physiotherapy group will receive individualized, exercise-based interventions designed to address aerobic capacity, muscle strength, spinal stabilization, balance, coordination, and flexibility. The intervention will be structured as follows:

Aerobic Exercise (10 minutes):

Horizontal cycling will be performed at a submaximal heart rate (60-80% of average). Room temperature will be kept at 20-22°C to prevent overheating.

Strengthening and Spinal Stabilization Exercises (20 minutes):

Exercises will target large muscle groups of the lower extremities (dorsiflexors, knee and hip extensors), the spine, and the shoulder girdle. Training will begin with 8-10 repetitions at 60-80% of one repetition maximum, progressing to two sets by week 2 and 15 repetitions by week 4. Resistance will be increased by 2-5% every three weeks. Rest intervals of 2-4 minutes will be allowed between exercises. Tactile feedback and instruction will be provided to ensure correct spinal stabilization techniques.

Balance and Coordination Exercises (20 minutes):

Training will progress from static to dynamic balance and will include dual-task activities. Difficulty will be gradually increased by performing tasks with eyes open and closed, shifting the center of gravity, and utilizing various balance-training materials. External support will be progressively reduced to encourage independence while maintaining motivation.

Stretching Exercises (10 minutes):

The final component of each session will involve active stretching of the hamstrings, hip flexors, adductors, quadriceps, and plantar flexors. Each stretch will be held for 20-60 seconds within the comfortable range of motion, ensuring that no pain is experienced. Straps will be provided as supportive aids when necessary.

Status Flow

~Oct 2025 – present · 6 months · monthly snapshotCompleted~Jan 2026 – present · 3 months · monthly snapshotCompleted

Change History

2 versions recorded
  1. Jan 2026 — Present [monthly]

    Completed NA

  2. Oct 2025 — Present [monthly]

    Completed NA

    First recorded

Mar 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Istanbul Rumeli University
Data source: Istanbul Rumeli University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations