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Recruiting INTERVENTIONAL NCT07158216

Long Term Effect of Brain Stimulation in PPA (RECONNECT-PLUS)

Long-term Effect of Transcranial Magnetic Stimulation and Transcranial Electrical Stimulation in Primary Progressive Aphasia: Randomized, Double-blind Clinical Trial (RECONNECT-PLUS)

Sponsor: Hospital San Carlos, Madrid

Conditions Primary Progressive Aphasia(PPA)
Interventions Sham TMS Sham tDCS TMS tDCS
Updated 2 times since 2025 Last updated: Apr 19, 2026 Started: Sep 15, 2025 Primary completion: Dec 1, 2028 Completion: Dec 1, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This observational or N/A phase trial investigates Primary Progressive Aphasia(PPA) and is currently actively recruiting participants. Hospital San Carlos, Madrid leads this study, which shows 2 recorded versions since 2025 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Study Description(click to expand)

Transcranial Magnetic Stimulation will follow an intermitent theta-burst protocol targetting the left dorsolateral prefrontal cortex. Transcranial electrical stimulation will also follow an excitatory protocol over the same region. All brain stimulation procedures will be conducted under neuronavigation. Language therapy will follow the lexical retrieval cascade protocol and will be conducted after each brain stimulation session.

Transcranial Magnetic Stimulation will follow an intermitent theta-burst protocol targetting the left dorsolateral prefrontal cortex. Transcranial electrical stimulation will also follow an excitatory protocol over the same region. All brain stimulation procedures will be conducted under neuronavigation. Language therapy will follow the lexical retrieval cascade protocol and will be conducted after each brain stimulation session.

Status Flow

~Oct 2025 – ~Apr 2026 · 7 months · monthly snapshotRecruitingApr 28, 2026 – present · 2 months · daily APIRecruiting

Change History

2 versions recorded

  1. Apr 28, 2026 — Present [daily]

    Recruiting

    Phase: NA → None

  2. Oct 2025 — Apr 2026 [monthly]

    Recruiting NA

    First recorded

Sep 2025

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

The goal of this clinical trial is to investigate the effect of non-invasive brain stimulation techniques in the progression of primary progressive aphasia for 6 months. We will compare three modalities of brain stimulation (TMS, tDCS, TMS+tDCS) against sham stimulation. All patients will receive also language therapy.

Contact Information

Sponsor contact:
  • Hospital San Carlos, Madrid
Data source: ClinicalTrials.gov

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations