deltatrials
Not Yet Recruiting INTERVENTIONAL NCT07535892

Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation

Pilot Trial of a Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Conditions GLP - 1 Obesity & Overweight Weight Loss Weight Loss Maintenance
Interventions Mom's Meals SKY Meditation Program Weight Loss Maintenance Program (Foundational) YMCA Membership
Updated 1 time since 2026 Last updated: Apr 10, 2026 Started: Jun 1, 2026 Primary completion: Nov 30, 2028 Completion: Feb 28, 2029
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This observational or N/A phase trial investigates GLP - 1 and Obesity & Overweight and is currently actively recruiting participants. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) leads this study, which shows 1 recorded version since 2026 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Apr 18, 2026 – present · 3 months · daily APINot Yet Recruiting

Change History

1 version recorded
Not Yet Recruiting [daily]

Eligibility Summary

This study is a single-site, pilot randomized factorial trial designed to evaluate the feasibility, acceptability, participant perceptions and preliminary effects of a multi-component behavioral intervention to support weight loss maintenance following discontinuation of GLP-1 and other anti-obesity medications. The intervention includes a standardized 10-week foundational weight loss maintenance program combined with candidate support components, including medically tailored meals, YMCA membership, and a structured mind-based program. Participants will be randomized using a 2 × 2 × 2 factorial design and followed for six months. Findings from this pilot study will inform optimization of a scalable intervention for future clinical trials.

Contact Information

Sponsor contact:
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  • National Institutes of Health (NIH)
  • University of Alabama at Birmingham
Data source: ClinicalTrials.gov

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations