Completed PHASE3 INTERVENTIONAL NCT00000173

Memory Impairment Study (Mild Cognitive Impairment Study)

A Randomized, Double-Blind, Placebo-Controlled Trial of Vitamin E and Donepezil HCL (Aricept) to Delay Clinical Progression From Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD)

Sponsor: Alzheimer's Disease Cooperative Study (ADCS)

Conditions Alzheimer Disease

Interventions Donepezil Vitamin E

Updated 6 times since 2017 Last updated: Dec 10, 2009 Started: Mar 31, 1999 Primary completion: Jan 31, 2004 Completion: Jan 31, 2004

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00000173, this PHASE3 trial focuses on Alzheimer Disease and remains completed. Sponsored by Alzheimer's Disease Cooperative Study (ADCS), it has been updated 6 times since 1999, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

6 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE3

▶ Show 1 earlier version

Jan 2017 — Jun 2018 [monthly]

Completed PHASE3

First recorded

Mar 1999

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Alzheimer's Disease Cooperative Study (ADCS)
National Institute on Aging (NIA)

Data source: National Institute on Aging (NIA)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albuquerque, United States , Ann Arbor, United States , Atlanta, United States , Augusta, United States , Baltimore, United States , Bennington, United States , Boca Raton, United States , Boston, United States , Brooklyn, United States , Burlington, United States and 54 more locations