Completed PHASE3 INTERVENTIONAL NCT00056225

VITAL - VITamins to Slow ALzheimer's Disease (Homocysteine Study)

High Dose Supplements to Reduce Homocysteine and Slow the Rate of Cognitive Decline in Alzheimer's Disease (Vitamins to Slow Alzheimer's - VITAL)

Sponsor: Alzheimer's Disease Cooperative Study (ADCS)

Conditions Alzheimer's Disease

Interventions Folate Vitamin B12 Vitamin B6

Updated 6 times since 2017 Last updated: Jun 10, 2009 Started: Jan 31, 2003 Primary completion: Jun 30, 2007 Completion: Jun 30, 2007

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00056225, this PHASE3 trial focuses on Alzheimer's Disease and remains completed. Sponsored by Alzheimer's Disease Cooperative Study (ADCS), it has been updated 6 times since 2003, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

6 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE3

▶ Show 1 earlier version

Jan 2017 — Jun 2018 [monthly]

Completed PHASE3

First recorded

Jan 2003

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Alzheimer's Disease Cooperative Study (ADCS)
National Institute on Aging (NIA)

Data source: National Institute on Aging (NIA)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Ann Arbor, United States , Atlanta, United States , Birmingham, United States , Boston, United States , Chicago, United States , Cleveland, United States , Dallas, United States , Houston, United States , Indianapolis, United States , Irvine, United States and 22 more locations