Completed NA INTERVENTIONAL NCT00000639

A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Conditions HIV Infections Meningitis, Cryptococcal

Interventions Amphotericin B Fluconazole Flucytosine Itraconazole

Updated 7 times since 2017 Last updated: Oct 26, 2021 Completion: Sep 30, 1997

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates HIV Infections and Meningitis, Cryptococcal and is currently completed. National Institute of Allergy and Infectious Diseases (NIAID) leads this study, which shows 7 recorded versions since 2026 — indicating limited longitudinal coverage. Longitudinal tracking of infectious disease trials helps identify durability of treatment effects.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed NA
Sep 2024 — Sep 2025 [monthly]

Completed NA
Jul 2024 — Sep 2024 [monthly]

Completed NA
Dec 2021 — Jul 2024 [monthly]

Completed NA
Jan 2021 — Dec 2021 [monthly]

Completed NA

▶ Show 2 earlier versions

Jun 2018 — Jan 2021 [monthly]

Completed NA
Jan 2017 — Jun 2018 [monthly]

Completed NA

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

National Institute of Allergy and Infectious Diseases (NIAID)
Washington University School of Medicine

Data source: National Institute of Allergy and Infectious Diseases (NIAID)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Boston, United States , Buffalo, United States , Chapel Hill, United States , Charlotte, United States , Chicago, United States , Cincinnati, United States , Columbus, United States , Greensboro, United States , Honolulu, United States , Indianapolis, United States and 9 more locations