Completed PHASE3 INTERVENTIONAL 2-arm NCT00003313

Amifostine in Treating Patients With Stage II or Stage III Non-small Cell Lung Cancer

A Phase III Randomized Study of Amifostine Mucosal Protection for Patients With Favorable Performance Inoperable Stage II-III A/B Non-Small Cell Lung Cancer (NSCLC) Receiving Sequential Induction and Concurrent Hyperfractionated Radiotherapy With Paclitaxel and Carboplatin

Sponsor: NRG Oncology

Conditions Drug/Agent Toxicity by Tissue/Organ Lung Cancer Oral Complications Radiation Toxicity

Interventions amifostine trihydrate carboplatin filgrastim paclitaxel radiation therapy

Updated 7 times since 2017 Last updated: Nov 19, 2014 Started: Sep 30, 1998 Primary completion: Jul 31, 2002 Completion: Jun 30, 2010

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Drug/Agent Toxicity by Tissue/Organ and Lung Cancer, this trial is completed. The trial is conducted by NRG Oncology and has accumulated 7 data snapshots since 1998. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE3

▶ Show 2 earlier versions

Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Sep 1998

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

NRG Oncology
National Cancer Institute (NCI)
Radiation Therapy Oncology Group

Data source: Radiation Therapy Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akron, United States , Albany, United States , Albuquerque, United States , Allentown, United States , Amarillo, United States , Anchorage, United States , Anderson, United States , Ann Arbor, United States , Annapolis, United States , Arlington Heights, United States and 195 more locations