Completed PHASE3 INTERVENTIONAL NCT00003596

Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer

A Phase III Randomized Study of 5-Fluorouracil, Mitomycin-C, and Radiotherapy Versus 5-Fluorouracil, Cisplatin, and Radiotherapy in Carcinoma of the Anal Canal

Sponsor: Cancer and Leukemia Group B

Conditions Anal Cancer

Interventions cisplatin fluorouracil mitomycin C radiation therapy

Updated 8 times since 2017 Last updated: Dec 30, 2016 Started: Oct 31, 1998 Primary completion: Oct 31, 2005 Completion: Dec 31, 2016

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00003596, this PHASE3 trial focuses on Anal Cancer and remains completed. Sponsored by Cancer and Leukemia Group B, it has been updated 8 times since 1998, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

Change History

8 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
May 2023 — Jul 2024 [monthly]

Completed PHASE3
Jan 2021 — May 2023 [monthly]

Completed PHASE3

▶ Show 3 earlier versions

Jun 2018 — Jan 2021 [monthly]

Completed PHASE3
Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Oct 1998

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Cancer and Leukemia Group B
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)
North Central Cancer Treatment Group
Radiation Therapy Oncology Group
SWOG Cancer Research Network

Data source: Radiation Therapy Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Adrian, United States , Akron, United States , Albuquerque, United States , Allentown, United States , Altanta, United States , Alton, United States , Amarillo, United States , Ames, United States , Anchorage, United States , Ann Arbor, United States and 309 more locations