Terminated PHASE3 INTERVENTIONAL 2-arm NCT00005776

Inhaled Nitric Oxide Study for Respiratory Failure in Newborns (NINOS)

The Randomized Inhaled Nitric Oxide Study (NINOS) in Full-Term and Nearly Full-Term Infants With Hypoxic Respiratory Failure

Sponsor: Medical Research Council of Canada

Conditions Hypertension, Pulmonary Infant, Newborn Persistent Fetal Circulation Syndrome Pneumonia, Aspiration Respiratory Distress Syndrome, Newborn Respiratory Insufficiency

Interventions Inhaled nitric oxide Placebo

Updated 8 times since 2017 Last updated: Sep 22, 2017 Started: Oct 31, 1995 Primary completion: May 31, 1996 Completion: May 31, 1998

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Results showed statistically significant benefit in the experimental group

Other Hypertension, Pulmonary trials with similar outcome

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A PHASE3 clinical study on Hypertension, Pulmonary and Infant, Newborn, this trial is terminated or withdrawn. The trial is conducted by Medical Research Council of Canada and has accumulated 8 data snapshots since 1995. Cardiovascular trials of this type often inform treatment guidelines for long-term patient management.

Status Flow

Change History

8 versions recorded

Sep 2025 — Present [monthly]

Terminated PHASE3
Sep 2024 — Sep 2025 [monthly]

Terminated PHASE3
Jul 2024 — Sep 2024 [monthly]

Terminated PHASE3
Jan 2021 — Jul 2024 [monthly]

Terminated PHASE3
Jun 2018 — Jan 2021 [monthly]

Terminated PHASE3

▶ Show 3 earlier versions

Oct 2017 — Jun 2018 [monthly]

Terminated PHASE3
Feb 2017 — Oct 2017 [monthly]

Terminated PHASE3
Jan 2017 — Feb 2017 [monthly]

Terminated PHASE3

First recorded

Oct 1995

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Medical Research Council of Canada
NICHD Neonatal Research Network
National Center for Research Resources (NCRR)

Data source: NICHD Neonatal Research Network

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albuquerque, United States , Calgary, Canada , Cincinnati, United States , Cleveland, United States , Detroit, United States , Edmonton, Canada , Hamilton, Canada , Houston, United States , Indianapolis, United States , Memphis, United States and 10 more locations