Completed PHASE3 INTERVENTIONAL 2-arm NCT00006349

Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer

An Exploratory Trial of Donepezil and Vitamin E to Prevent Cognitive Dysfunction in Patients With Small Cell Lung Cancer (SCLC) After Cancer Treatment Which Includes Prophylatic Cranial Irradiation (PCI)

Sponsor: Alliance for Clinical Trials in Oncology

Conditions Cognitive/Functional Effects Delirium Depression Lung Cancer Radiation Toxicity

Interventions donepezil hydrochloride placebo vitamin E

Updated 6 times since 2017 Last updated: Jul 12, 2016 Started: Feb 28, 2001 Primary completion: Jan 31, 2005 Completion: Jan 31, 2007

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Cognitive/Functional Effects and Delirium, this trial is completed. The trial is conducted by Alliance for Clinical Trials in Oncology and has accumulated 6 data snapshots since 2001. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

6 versions recorded

Sep 2024 — Present [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE3
Feb 2017 — Jun 2018 [monthly]

Completed PHASE3

▶ Show 1 earlier version

Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Feb 2001

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Data source: Alliance for Clinical Trials in Oncology

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Bismarck, United States , Cedar Rapids, United States , Des Moines, United States , Fargo, United States , Jacksonville, United States , Omaha, United States , Peoria, United States , Pittsburgh, United States , Rapid City, United States , Rochester, United States and 5 more locations