Completed PHASE3 INTERVENTIONAL NCT00026286

Hormone Replacement Therapy for Hot Flashes and/or Vaginal Symptoms in Postmenopausal Women Receiving Tamoxifen for Breast Cancer

A Phase III Prospective, Randomized, Double-Blind Clinical Trial of Hormone Replacement Therapy In Postmenopausal Women With A History Of Node-Negative Or Ductal Carcinoma In Situ Who Are Receiving Adjuvant Tamoxifen

Sponsor: Eastern Cooperative Oncology Group

Conditions Breast Cancer Hot Flashes Menopausal Symptoms

Interventions conjugated estrogens medroxyprogesterone

Updated 8 times since 2017 Last updated: Jun 14, 2023 Started: Nov 28, 2000 Primary completion: Aug 31, 2002 Completion: Jun 15, 2007

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Breast Cancer and Hot Flashes and is currently completed. Eastern Cooperative Oncology Group leads this study, which shows 8 recorded versions since 2000 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

Change History

8 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jul 2023 — Jul 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2023 [monthly]

Completed PHASE3

▶ Show 3 earlier versions

Feb 2019 — Jan 2021 [monthly]

Completed PHASE3
Jun 2018 — Feb 2019 [monthly]

Completed PHASE3
Jan 2017 — Jun 2018 [monthly]

Completed PHASE3

First recorded

Nov 2000

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Data source: Eastern Cooperative Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Ann Arbor, United States , Birmingham, United States , Chicago, United States , Cleveland, United States , Decatur, United States , Fargo, United States , Hackensack, United States , Indianapolis, United States , Kalamazoo, United States , Madison, United States and 9 more locations