deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT00044304

Tyrosine Kinase Inhibition to Treat Myeloid Hypereosinophilic Syndrome

Efficacy of Tyrosine Kinase Inhibition in Reducing Eosinophilia in Patients With Myeloid and/or Steroid-Refractory Hypereosinophilic Syndrome

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Conditions Eosinophilic Myeloid Neoplasm Hypereosinophilic Syndrome
Interventions Imatinib Ruxolitinib
Updated 76 times since 2017 Last updated: Mar 6, 2026 Started: Sep 26, 2002 Primary completion: Mar 10, 2026 Completion: Mar 10, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Eosinophilic Myeloid Neoplasm and Hypereosinophilic Syndrome and is currently ongoing. National Institute of Allergy and Infectious Diseases (NIAID) leads this study, which shows 76 recorded versions since 2002 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2018 · 13 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Feb 2019 · 5 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Oct 2019 · 6 months · monthly snapshot~Oct 2019 – ~Jan 2020 · 3 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Jan 2026 · 3 months · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – ~Mar 2026 · 28 days · monthly snapshot~Mar 2026 – present · 3 months · monthly snapshot

Change History

76 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  2. Feb 2026 — Mar 2026 [monthly]

    Recruiting PHASE2

  3. Jan 2026 — Feb 2026 [monthly]

    Recruiting PHASE2

  4. Oct 2025 — Jan 2026 [monthly]

    Recruiting PHASE2

  5. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE2

▶ Show 71 earlier versions

  1. Aug 2025 — Sep 2025 [monthly]

    Recruiting PHASE2

  2. Jul 2025 — Aug 2025 [monthly]

    Recruiting PHASE2

  3. Jun 2025 — Jul 2025 [monthly]

    Recruiting PHASE2

  4. May 2025 — Jun 2025 [monthly]

    Recruiting PHASE2

  5. Apr 2025 — May 2025 [monthly]

    Recruiting PHASE2

  6. Mar 2025 — Apr 2025 [monthly]

    Recruiting PHASE2

  7. Feb 2025 — Mar 2025 [monthly]

    Recruiting PHASE2

  8. Jan 2025 — Feb 2025 [monthly]

    Recruiting PHASE2

  9. Dec 2024 — Jan 2025 [monthly]

    Recruiting PHASE2

  10. Nov 2024 — Dec 2024 [monthly]

    Recruiting PHASE2

  11. Oct 2024 — Nov 2024 [monthly]

    Recruiting PHASE2

  12. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE2

  13. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  14. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2

  15. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  16. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE2

  17. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE2

  18. Mar 2024 — Apr 2024 [monthly]

    Recruiting PHASE2

  19. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE2

  20. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE2

  21. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE2

  22. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE2

  23. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  24. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

  25. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  26. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  27. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE2

  28. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE2

  29. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2

  30. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  31. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE2

  32. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE2

  33. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  34. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  35. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE2

  36. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  37. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  38. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  39. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE2

  40. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE2

  41. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE2

  42. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE2

  43. Nov 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  44. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  45. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  46. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  47. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  48. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  49. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  50. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  51. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  52. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  53. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  54. Sep 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  55. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  56. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  57. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  58. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  59. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2

  60. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  61. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  62. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  63. Oct 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  64. Apr 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  65. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  66. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  67. Sep 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  68. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  69. May 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  70. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE2

  71. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Sep 2002

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Institute of Allergy and Infectious Diseases (NIAID)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations