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Terminated PHASE3 INTERVENTIONAL 1-arm NCT00097370

Open-Label Extension Of Intravenous Mepolizumab In Patients With Hypereosinophilic Syndrome

An Open Label Extension Study to Evaluate Safety and Efficacy of Mepolizumab in Patients With Hypereosinophilic Syndromes

Sponsor: GlaxoSmithKline

Interventions mepolizumab
Updated 11 times since 2017 Last updated: Jun 7, 2017 Started: Sep 30, 2004 Primary completion: Sep 29, 2010 Completion: Sep 29, 2010
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Study terminated by sponsor (29 Sep 2010). Subjects eligible to continue mepolizumab treatment were transferred into the compassionate use program (MHE104317)

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Listed as NCT00097370, this PHASE3 trial focuses on Hypereosinophilic Syndrome and remains terminated or withdrawn. Sponsored by GlaxoSmithKline, it has been updated 11 times since 2004, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotTerminated~Feb 2017 – ~Aug 2017 · 6 months · monthly snapshotTerminated~Aug 2017 – ~May 2018 · 9 months · monthly snapshotTerminated~May 2018 – ~Jun 2018 · 31 days · monthly snapshotTerminated~Jun 2018 – ~Nov 2020 · 29 months · monthly snapshotTerminated~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshotTerminated~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshotTerminated~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotTerminated~Sep 2025 – present · 9 months · monthly snapshotTerminated

Change History

11 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE3

  4. Dec 2021 — Jul 2024 [monthly]

    Terminated PHASE3

  5. Jan 2021 — Dec 2021 [monthly]

    Terminated PHASE3

Show 6 earlier versions
  1. Nov 2020 — Jan 2021 [monthly]

    Terminated PHASE3

  2. Jun 2018 — Nov 2020 [monthly]

    Terminated PHASE3

  3. May 2018 — Jun 2018 [monthly]

    Terminated PHASE3

  4. Aug 2017 — May 2018 [monthly]

    Terminated PHASE3

  5. Feb 2017 — Aug 2017 [monthly]

    Terminated PHASE3

  6. Jan 2017 — Feb 2017 [monthly]

    Terminated PHASE3

    First recorded

Sep 2004

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • GlaxoSmithKline
Data source: GlaxoSmithKline

For direct contact, visit the study record on ClinicalTrials.gov .