Completed PHASE2 INTERVENTIONAL 1-arm NCT00068237

Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer

A Phase II Study Of Submandibular Salivary Gland Transfer To The Submental Space Prior To Start Of Radiation Treatment For Prevention Of Radiation-Induced Xerostomia In Head And Neck Cancer Patients

Sponsor: National Cancer Institute (NCI)

Conditions Head and Neck Cancer Radiation Toxicity Xerostomia

Interventions Post-operative radiation therapy salivary gland transfer

Updated 8 times since 2017 Last updated: Feb 1, 2019 Started: Aug 31, 2003 Primary completion: Jan 31, 2008 Completion: Dec 31, 2016

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00068237, this PHASE2 trial focuses on Head and Neck Cancer and Radiation Toxicity and remains completed. Sponsored by National Cancer Institute (NCI), it has been updated 8 times since 2003, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

Change History

8 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2
Jan 2021 — Jul 2024 [monthly]

Completed PHASE2
Mar 2019 — Jan 2021 [monthly]

Completed PHASE2

▶ Show 3 earlier versions

Jun 2018 — Mar 2019 [monthly]

Completed PHASE2
Feb 2017 — Jun 2018 [monthly]

Completed PHASE2
Jan 2017 — Feb 2017 [monthly]

Completed PHASE2

First recorded

Aug 2003

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

National Cancer Institute (NCI)
Radiation Therapy Oncology Group

Data source: Radiation Therapy Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Charleston, United States , Columbus, United States , Detroit, United States , Edmonton, Canada , Gainesville, United States , Houston, United States , Miami, United States , Milwaukee, United States , Québec, Canada , Springfield, United States and 1 more location