Completed PHASE3 INTERVENTIONAL 5-arm NCT00101686

Trial Of Irinotecan In Combination With Three Methods Of Administration Of Fluoropyrimidine.

A Randomized, Multi-Center Phase III Trial Of Irinotecan In Combination With Three Different Methods Of Administration Of Fluoropyrimidine: Infusional 5-FU (FOLFIRI), Modified-Bolus 5-FU (Day 1 & 8), And Oral Capecitabine (Day 1-14); With Celecoxib Versus Placebo As First-Line Treatment For Patients With Metastatic Colorectal Cancer Study Amended April 23, 2004 To Include Bevacizumab

Sponsor: Pfizer

Conditions Colorectal Neoplasms

Interventions FOLFIRI + bevacizumab Infusional 5-FU/LV with Irinotecan Modified Bolus 5-FU/LV with Irinotecan Oral Capecitabine with Irinotecan miFL + bevacizumab

Updated 7 times since 2017 Last updated: Jan 4, 2010 Started: Feb 28, 2003 Primary completion: Oct 31, 2008 Completion: Oct 31, 2008

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Colorectal Neoplasms, this trial is completed. The trial is conducted by Pfizer and has accumulated 7 data snapshots since 2003. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE3

▶ Show 2 earlier versions

Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Feb 2003

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Pfizer

Data source: Pfizer

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Abilene, United States , Abington, United States , Albany, United States , Albuquerque, United States , Alexandria, United States , Altamonte Springs, United States , Annapolis, United States , Arlington, United States , Arroyo Grande, United States , Asheville, United States and 148 more locations