Completed PHASE2 INTERVENTIONAL 3-arm NCT00111839

Effects of Matuzumab in Combination With Pemetrexed for the Treatment of Advanced Lung Cancer

Randomized, Phase II, Open-Label Controlled Study of Two Different Doses and Schedules of EMD 72000 (Matuzumab) in Combination With Pemetrexed, or Pemetrexed Alone, as Second-Line Treatment for Stage IIIB/IV Non-Small Cell Lung Cancer and Progressive Disease on or After First-Line Treatment With a Platinum in Combination With Taxanes, Gemcitabine and Vinorelbine

Sponsor: EMD Serono

Conditions Lung Cancer Non Small Cell Lung Carcinoma

Interventions Matuzumab Pemetrexed

Updated 9 times since 2017 Last updated: Apr 5, 2018 Started: May 31, 2005 Primary completion: Jul 31, 2007 Completion: Mar 31, 2009

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00111839, this PHASE2 trial focuses on Lung Cancer and Non Small Cell Lung Carcinoma and remains completed. Sponsored by EMD Serono, it has been updated 9 times since 2005, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

Change History

9 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2
Dec 2021 — Jul 2024 [monthly]

Completed PHASE2
Jan 2021 — Dec 2021 [monthly]

Completed PHASE2

▶ Show 4 earlier versions

Jun 2018 — Jan 2021 [monthly]

Completed PHASE2
May 2018 — Jun 2018 [monthly]

Completed PHASE2
Feb 2017 — May 2018 [monthly]

Completed PHASE2
Jan 2017 — Feb 2017 [monthly]

Completed PHASE2

First recorded

May 2005

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

EMD Serono

Data source: EMD Serono

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albany, United States , Atlanta, United States , Baton Rouge, United States , Billings, United States , Boston, United States , Chapel Hill, United States , Charlotte, United States , Chicago, United States , Cleveland, United States , Cologne, Germany and 45 more locations