deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 2-arm NCT00238420

Paclitaxel and Radiation Therapy With or Without Trastuzumab in Treating Patients Who Have Undergone Surgery for Bladder Cancer

A Phase I/II Trial of a Combination of Paclitaxel and Trastuzumab With Daily Irradiation or Paclitaxel Alone With Daily Irradiation Following Transurethral Surgery for Non-Cystectomy Candidates With Muscle-Invasive Bladder Cancer

Sponsor: National Cancer Institute (NCI)

Conditions Bladder Urothelial Carcinoma Stage I Bladder Cancer AJCC v6 and v7 Stage II Bladder Cancer AJCC v6 and v7 Stage III Bladder Cancer AJCC v6 and v7
Interventions Paclitaxel Radiation Therapy Trastuzumab
Updated 34 times since 2017 Last updated: Jun 28, 2022 Started: Jul 26, 2005 Primary completion: Feb 5, 2014 Completion: May 20, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1/PHASE2 clinical study on Bladder Urothelial Carcinoma and Stage I Bladder Cancer AJCC v6 and v7, this trial is completed. The trial is conducted by National Cancer Institute (NCI) and has accumulated 34 data snapshots since 2005. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Dec 2017 · 10 months · monthly snapshot~Dec 2017 – ~Feb 2018 · 2 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Jan 2019 · 4 months · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jul 2019 · 3 months · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Sep 2022 · 8 months · monthly snapshot~Sep 2022 – ~Jul 2024 · 22 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

34 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE1/PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  4. Sep 2022 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

  5. Jan 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

▶ Show 29 earlier versions

  1. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  2. Oct 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  3. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  4. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  5. Apr 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  6. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  7. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  8. Oct 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  9. Sep 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  10. Jul 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  11. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  12. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  13. Mar 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  14. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  15. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  16. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  17. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  18. Sep 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  19. Jul 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  20. Apr 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  21. Mar 2019 — Apr 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  22. Jan 2019 — Mar 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  23. Sep 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  24. Aug 2018 — Sep 2018 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Completed → Active Not Recruiting

  25. Jun 2018 — Aug 2018 [monthly]

    Completed PHASE1_PHASE2

  26. Feb 2018 — Jun 2018 [monthly]

    Completed PHASE1_PHASE2

  27. Dec 2017 — Feb 2018 [monthly]

    Completed PHASE1_PHASE2

  28. Feb 2017 — Dec 2017 [monthly]

    Completed PHASE1_PHASE2

  29. Jan 2017 — Feb 2017 [monthly]

    Completed PHASE1_PHASE2

    First recorded

Jul 2005

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
  • Radiation Therapy Oncology Group
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akron, United States , Ames, United States , Anchorage, United States , Ann Arbor, United States , Auburn, United States , Aurora, United States , Barberton, United States , Billings, United States , Bismarck, United States , Bloomington, United States and 109 more locations