deltatrials
Completed PHASE1 INTERVENTIONAL NCT00272350

ZD6474 to Treat Advanced Brain Cancer in Patients

A Phase I/II Trial of ZD6474 for Patients With Recurrent High-Grade and Progressive Low-Grade Gliomas

Sponsor: National Cancer Institute (NCI)

Conditions Malignant Gliomas Progressive Low-Grade Gliomas Recurrent High-Grade Gliomas
Interventions Steroids ZD6474
Updated 24 times since 2017 Last updated: Dec 4, 2019 Started: Dec 29, 2005 Primary completion: Feb 27, 2014 Completion: Feb 27, 2014
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Malignant Gliomas and Progressive Low-Grade Gliomas, this trial is completed. The trial is conducted by National Cancer Institute (NCI) and has accumulated 24 data snapshots since 2005. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Jan 2021 · 12 months · monthly snapshot~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 23 months · monthly snapshot

Change History

24 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE1

  4. Jan 2020 — Jan 2021 [monthly]

    Completed PHASE1

  5. Dec 2019 — Jan 2020 [monthly]

    Completed PHASE1

▶ Show 19 earlier versions

  1. Nov 2019 — Dec 2019 [monthly]

    Completed PHASE1

  2. Oct 2019 — Nov 2019 [monthly]

    Completed PHASE1

  3. Sep 2019 — Oct 2019 [monthly]

    Completed PHASE1

  4. Aug 2019 — Sep 2019 [monthly]

    Completed PHASE1

  5. Jul 2019 — Aug 2019 [monthly]

    Completed PHASE1

  6. Jun 2019 — Jul 2019 [monthly]

    Completed PHASE1

  7. May 2019 — Jun 2019 [monthly]

    Completed PHASE1

  8. Apr 2019 — May 2019 [monthly]

    Completed PHASE1

  9. Mar 2019 — Apr 2019 [monthly]

    Completed PHASE1

  10. Feb 2019 — Mar 2019 [monthly]

    Completed PHASE1

  11. Dec 2018 — Feb 2019 [monthly]

    Completed PHASE1

  12. Nov 2018 — Dec 2018 [monthly]

    Completed PHASE1

  13. Oct 2018 — Nov 2018 [monthly]

    Completed PHASE1

  14. Sep 2018 — Oct 2018 [monthly]

    Completed PHASE1

  15. Aug 2018 — Sep 2018 [monthly]

    Completed PHASE1

  16. Jul 2018 — Aug 2018 [monthly]

    Completed PHASE1

  17. Jun 2018 — Jul 2018 [monthly]

    Completed PHASE1

  18. Feb 2017 — Jun 2018 [monthly]

    Completed PHASE1

  19. Jan 2017 — Feb 2017 [monthly]

    Completed PHASE1

    First recorded

Dec 2005

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations