deltatrials
Completed PHASE3 INTERVENTIONAL 17-arm NCT00408005

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma

Intensified Methotrexate, Nelarabine (Compound 506U78) and Augmented BFM Therapy for Children and Young Adults With Newly Diagnosed T-cell Acute Lymphoblastic Leukemia (ALL) or T-cell Lymphoblastic Lymphoma

Sponsor: National Cancer Institute (NCI)

Updated 43 times since 2017 Last updated: Apr 2, 2025 Started: Jan 30, 2007 Primary completion: Sep 30, 2017 Completion: Mar 31, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00408005, this PHASE3 trial focuses on T Acute Lymphoblastic Leukemia and T Lymphoblastic Lymphoma and remains completed. Sponsored by National Cancer Institute (NCI), it has been updated 43 times since 2007, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Oct 2017 · 2 months · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Jul 2019 · 12 months · monthly snapshot~Jul 2019 – ~May 2020 · 10 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Dec 2020 · 5 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Oct 2021 · 4 months · monthly snapshot~Oct 2021 – ~Apr 2022 · 6 months · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Feb 2023 · 3 months · monthly snapshot~Feb 2023 – ~May 2023 · 3 months · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Oct 2023 · 4 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~May 2024 · 2 months · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Sep 2025 · 4 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

43 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. May 2025 — Sep 2025 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  3. Mar 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE3

Show 38 earlier versions
  1. Nov 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  5. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  6. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

  7. Mar 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE3

  8. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE3

  9. Dec 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE3

  10. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  11. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  12. Jun 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  13. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  14. Feb 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  15. Nov 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  16. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

  17. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  18. May 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE3

  19. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE3

  20. Oct 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  21. Jun 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE3

  22. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE3

  23. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE3

  24. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE3

  25. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE3

  26. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  27. Jul 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE3

  28. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  29. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE3

    Status: CompletedActive Not Recruiting

  30. Jul 2019 — May 2020 [monthly]

    Completed PHASE3

  31. Jul 2018 — Jul 2019 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  32. Jun 2018 — Jul 2018 [monthly]

    Active Not Recruiting PHASE3

  33. Dec 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  34. Oct 2017 — Dec 2017 [monthly]

    Active Not Recruiting PHASE3

  35. Aug 2017 — Oct 2017 [monthly]

    Active Not Recruiting PHASE3

  36. Jun 2017 — Aug 2017 [monthly]

    Active Not Recruiting PHASE3

  37. Feb 2017 — Jun 2017 [monthly]

    Active Not Recruiting PHASE3

  38. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE3

    First recorded

Jan 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .