deltatrials
Recruiting PHASE2 INTERVENTIONAL 1-arm NCT00501826

Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Phase II Study of Hyper-CVAD Plus Nelarabine in Previously Untreated T-ALL and Lymphoblastic Lymphoma

Sponsor: M.D. Anderson Cancer Center

Conditions T Acute Lymphoblastic Leukemia T Lymphoblastic Lymphoma
Interventions Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Hydrochloride Mercaptopurine Methotrexate Nelarabine Pegaspargase Prednisone Venetoclax Vincristine Sulfate
Updated 24 times since 2017 Last updated: Jan 5, 2026 Started: Jul 11, 2007 Primary completion: Oct 31, 2026 Completion: Oct 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on T Acute Lymphoblastic Leukemia and T Lymphoblastic Lymphoma, this trial is actively recruiting participants. The trial is conducted by M.D. Anderson Cancer Center and has accumulated 24 data snapshots since 2007. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Aug 2017 · 6 months · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Dec 2017 · 3 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Dec 2018 · 6 months · monthly snapshot~Dec 2018 – ~Jun 2019 · 6 months · monthly snapshot~Jun 2019 – ~Nov 2019 · 5 months · monthly snapshot~Nov 2019 – ~Jan 2021 · 14 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Jan 2022 · 8 months · monthly snapshot~Jan 2022 – ~Jul 2022 · 6 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~Aug 2023 · 6 months · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Apr 2024 · 6 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Jan 2025 · 3 months · monthly snapshot~Jan 2025 – ~Aug 2025 · 7 months · monthly snapshot~Aug 2025 – ~Feb 2026 · 6 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

24 versions recorded

  1. Feb 2026 — Present [monthly]

    Recruiting PHASE2

  2. Aug 2025 — Feb 2026 [monthly]

    Recruiting PHASE2

  3. Jan 2025 — Aug 2025 [monthly]

    Recruiting PHASE2

  4. Oct 2024 — Jan 2025 [monthly]

    Recruiting PHASE2

  5. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE2

▶ Show 19 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  2. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  3. Oct 2023 — Apr 2024 [monthly]

    Recruiting PHASE2

  4. Aug 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

  5. Feb 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  6. Sep 2022 — Feb 2023 [monthly]

    Recruiting PHASE2

  7. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  8. Jan 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  9. May 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  10. Jan 2021 — May 2021 [monthly]

    Recruiting PHASE2

  11. Nov 2019 — Jan 2021 [monthly]

    Recruiting PHASE2

  12. Jun 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  13. Dec 2018 — Jun 2019 [monthly]

    Recruiting PHASE2

  14. Jun 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  15. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  16. Sep 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

    Status: Active Not Recruiting → Recruiting

  17. Aug 2017 — Sep 2017 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  18. Feb 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  19. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Jul 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
  • National Cancer Institute (NCI)
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations