deltatrials
Completed PHASE2 NCT00477594

Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial Hypercholesterolemia

An Open-Label Extension Study to Assess the Long-term Safety and Efficacy of Mipomersen in Subjects With Familial Hypercholesterolemia

Sponsor: Ionis Pharmaceuticals, Inc.

Interventions mipomersen sodium
Updated 6 times since 2017 Last updated: Aug 1, 2016 Started: May 31, 2007 Primary completion: Mar 31, 2011 Completion: Jul 31, 2011

This PHASE2 trial investigates Congenital Abnormalities and Dyslipidemias and is currently completed. Ionis Pharmaceuticals, Inc. leads this study, which shows 6 recorded versions since 2007 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotCompleted~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshotCompleted~Jun 2018 – ~Jan 2021 · 31 months · monthly snapshotCompleted~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – present · 19 months · monthly snapshotCompleted

Change History

6 versions recorded
  1. Sep 2024 — Present [monthly]

    Completed PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  3. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE2

  4. Jun 2018 — Jan 2021 [monthly]

    Completed PHASE2

  5. Feb 2017 — Jun 2018 [monthly]

    Completed PHASE2

Show 1 earlier version
  1. Jan 2017 — Feb 2017 [monthly]

    Completed PHASE2

    First recorded

May 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Ionis Pharmaceuticals, Inc.
  • Kastle Therapeutics, LLC
Data source: Kastle Therapeutics, LLC

For direct contact, visit the study record on ClinicalTrials.gov .