deltatrials
Terminated PHASE3 NCT00520975

Bevacizumab in Treating Patients With Metastatic Breast Cancer That Overexpresses HER-2/NEU

A Randomized Phase III Double-Blind Placebo-Controlled Trial of First-Line Chemotherapy and Trastuzumab With or Without Bevacizumab for Patients With HER-2/NEU Over-Expressing Metastatic Breast Cancer

Sponsor: National Cancer Institute (NCI)

Updated 8 times since 2017 Last updated: Mar 18, 2025 Started: Nov 30, 2007 Primary completion: Oct 31, 2015 Completion: Oct 31, 2015

A PHASE3 clinical study on Breast Carcinoma and Recurrent Breast Carcinoma, this trial is terminated or withdrawn. The trial is conducted by National Cancer Institute (NCI) and has accumulated 8 data snapshots since 2007. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotTerminated~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshotTerminated~Jun 2018 – ~Jan 2021 · 31 months · monthly snapshotTerminated~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshotTerminated~Apr 2025 – ~Sep 2025 · 5 months · monthly snapshotTerminated~Sep 2025 – present · 7 months · monthly snapshotTerminated

Change History

8 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Apr 2025 — Sep 2025 [monthly]

    Terminated PHASE3

  3. Sep 2024 — Apr 2025 [monthly]

    Terminated PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE3

  5. Jan 2021 — Jul 2024 [monthly]

    Terminated PHASE3

Show 3 earlier versions
  1. Jun 2018 — Jan 2021 [monthly]

    Terminated PHASE3

  2. Feb 2017 — Jun 2018 [monthly]

    Terminated PHASE3

  3. Jan 2017 — Feb 2017 [monthly]

    Terminated PHASE3

    First recorded

Nov 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .