deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT00548717

Sirolimus, Mycophenolate Mofetil and Bortezomib as Graft-Versus-Host Disease (GVHD) Prophylaxis After Reduced Intensity Conditioning (RIC) Hematopoietic Stem Cell Transplantation

Sirolimus, Mycophenolate Mofetil and Bortezomib as Graft-Versus-Host Disease Prophylaxis After Non-Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation

Sponsor: Dana-Farber Cancer Institute

Updated 10 times since 2017 Last updated: Oct 20, 2014 Started: Oct 31, 2007 Primary completion: Sep 30, 2013 Completion: Sep 30, 2013
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

First two patients enrolled after trial reopened, developed grade III-IV acute GVHD and subsequently passed away.

Listed as NCT00548717, this PHASE2 trial focuses on Graft-vs-Host Disease and remains terminated or withdrawn. Sponsored by Dana-Farber Cancer Institute, it has been updated 10 times since 2007, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotTerminated~Feb 2017 – ~Aug 2017 · 6 months · monthly snapshotTerminated~Aug 2017 – ~May 2018 · 9 months · monthly snapshotTerminated~May 2018 – ~Jun 2018 · 31 days · monthly snapshotTerminated~Jun 2018 – ~Nov 2020 · 29 months · monthly snapshotTerminated~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshotTerminated~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshotTerminated~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – present · 22 months · monthly snapshotTerminated

Change History

10 versions recorded
  1. Sep 2024 — Present [monthly]

    Terminated PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  3. Dec 2021 — Jul 2024 [monthly]

    Terminated PHASE2

  4. Jan 2021 — Dec 2021 [monthly]

    Terminated PHASE2

  5. Nov 2020 — Jan 2021 [monthly]

    Terminated PHASE2

Show 5 earlier versions
  1. Jun 2018 — Nov 2020 [monthly]

    Terminated PHASE2

  2. May 2018 — Jun 2018 [monthly]

    Terminated PHASE2

  3. Aug 2017 — May 2018 [monthly]

    Terminated PHASE2

  4. Feb 2017 — Aug 2017 [monthly]

    Terminated PHASE2

  5. Jan 2017 — Feb 2017 [monthly]

    Terminated PHASE2

    First recorded

Oct 2007

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Dana-Farber Cancer Institute
  • PDL BioPharma, Inc.
  • Wyeth is now a wholly owned subsidiary of Pfizer
Data source: Dana-Farber Cancer Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations