deltatrials
Terminated PHASE2 INTERVENTIONAL 1-arm NCT03747419

Avelumab and Radiation in Muscle-Invasive Bladder Cancer

A Phase 2 Study of Avelumab in Combination With Bladder-Directed Radiation in Cisplatin-Ineligible Patients With Muscle-Invasive Urothelial Carcinoma of the Bladder

Sponsor: Dana-Farber Cancer Institute

Updated 16 times since 2018 Last updated: Oct 6, 2025 Started: Dec 13, 2018 Primary completion: Feb 24, 2025 Completion: Feb 24, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

In agreement with the drug sponsor and the institution, the trial has been terminated due to slow accrual.

Listed as NCT03747419, this PHASE2 trial focuses on Bladder Cancer and Muscle Invasive Bladder Cancer and remains terminated or withdrawn. Sponsored by Dana-Farber Cancer Institute, it has been updated 16 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Dec 2018 – ~Mar 2019 · 3 months · monthly snapshot~Mar 2019 – ~May 2020 · 14 months · monthly snapshot~May 2020 – ~Jan 2021 · 8 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Sep 2021 · 6 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~May 2022 · 7 months · monthly snapshot~May 2022 – ~Jun 2023 · 13 months · monthly snapshot~Jun 2023 – ~Jun 2024 · 12 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Mar 2025 · 3 months · monthly snapshot~Mar 2025 – ~Jun 2025 · 3 months · monthly snapshot~Jun 2025 – ~Nov 2025 · 5 months · monthly snapshot~Nov 2025 – present · 10 months · monthly snapshot

Change History

16 versions recorded
  1. Nov 2025 — Present [monthly]

    Terminated PHASE2

  2. Jun 2025 — Nov 2025 [monthly]

    Terminated PHASE2

  3. Mar 2025 — Jun 2025 [monthly]

    Terminated PHASE2

    Status: RecruitingTerminated

  4. Dec 2024 — Mar 2025 [monthly]

    Recruiting PHASE2

  5. Sep 2024 — Dec 2024 [monthly]

    Recruiting PHASE2

Show 11 earlier versions
  1. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  2. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  3. Jun 2023 — Jun 2024 [monthly]

    Recruiting PHASE2

  4. May 2022 — Jun 2023 [monthly]

    Recruiting PHASE2

    Status: Active Not RecruitingRecruiting

  5. Oct 2021 — May 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  6. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  7. Mar 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  8. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  9. May 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  10. Mar 2019 — May 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  11. Dec 2018 — Mar 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Dana-Farber Cancer Institute
  • EMD Serono
Data source: Dana-Farber Cancer Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations