Completed PHASE1 INTERVENTIONAL 2-arm NCT00634504

Open-label Leucovorin Pharmacokinetic Study in Patients Receiving High Dose Methotrexate With or Without Voraxaze (LVPK)

An Open-Label Study to Assess the Pharmacokinetics of Leucovorin in Patients Receiving High Dose Methotrexate, With or Without Voraxaze Treatment

Sponsor: BTG International Inc.

Conditions Leukemia Lymphoma Osteosarcoma

Interventions glucarpidase, high-dose methotrexate, leucovorin high-dose methotrexate, leucovorin

Updated 8 times since 2017 Last updated: May 13, 2022 Started: May 31, 2008 Primary completion: Aug 31, 2009 Completion: Aug 31, 2009

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Leukemia and Lymphoma, this trial is completed. The trial is conducted by BTG International Inc. and has accumulated 8 data snapshots since 2008. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

8 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE1
Sep 2024 — Sep 2025 [monthly]

Completed PHASE1
Jul 2024 — Sep 2024 [monthly]

Completed PHASE1
Jul 2022 — Jul 2024 [monthly]

Completed PHASE1
Jan 2021 — Jul 2022 [monthly]

Completed PHASE1

▶ Show 3 earlier versions

Jun 2018 — Jan 2021 [monthly]

Completed PHASE1
Feb 2017 — Jun 2018 [monthly]

Completed PHASE1
Jan 2017 — Feb 2017 [monthly]

Completed PHASE1

First recorded

May 2008

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

BTG International Inc.

Data source: BTG International Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aurora, United States , Canton, United States , Columbia, United States , Evanston, United States , Greenville, United States , Hackensack, United States , Houston, United States , Indianapolis, United States , Jackson, United States , Lexington, United States and 13 more locations