Study of Molecular Response in Adult Patients on Nilotinib With Philadelphia Chromosome Positive Chronic Myelogenous Leukemia (Ph+ CML) in Chronic Phase and a Suboptimal Molecular Response to Imatinib (MACS0254)
A Multi-center, Open-label, Exploratory Study of Bcr-Abl Kinetics in Adult Patients on Nilotinib With Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) and a Suboptimal Molecular Response to Imatinib
Sponsor: Novartis Pharmaceuticals
Terminated
Slower than expected enrollment
A PHASE2 clinical study on Chronic Myelogenous Leukemia - Chronic Phase, this trial is terminated or withdrawn. The trial is conducted by Novartis Pharmaceuticals and has accumulated 8 data snapshots since 2008. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.
Status Flow
Change History
8 versions recorded-
Sep 2024 — Present [monthly]
Terminated PHASE2
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Jul 2024 — Sep 2024 [monthly]
Terminated PHASE2
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Dec 2021 — Jul 2024 [monthly]
Terminated PHASE2
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Sep 2021 — Dec 2021 [monthly]
Terminated PHASE2
Status: Completed → Terminated · Phase: PHASE4 → PHASE2
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Jan 2021 — Sep 2021 [monthly]
Completed PHASE4
▶ Show 3 earlier versions
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Jun 2018 — Jan 2021 [monthly]
Completed PHASE4
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Feb 2017 — Jun 2018 [monthly]
Completed PHASE4
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Jan 2017 — Feb 2017 [monthly]
Completed PHASE4
First recorded
Oct 2008
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Novartis Pharmaceuticals
For direct contact, visit the study record on ClinicalTrials.gov .