deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT00769379

Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy

A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently With Radiation Therapy and Radiation Therapy Alone for Women With HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy

Sponsor: NRG Oncology

Conditions Breast Ductal Carcinoma In Situ
Interventions Laboratory Biomarker Analysis Trastuzumab Whole Breast Irradiation
Updated 72 times since 2017 Last updated: Jun 3, 2025 Started: Dec 10, 2008 Primary completion: Dec 31, 2019 Completion: Jun 2, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00769379, this PHASE3 trial focuses on Breast Ductal Carcinoma In Situ and remains completed. Sponsored by NRG Oncology, it has been updated 72 times since 2008, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Oct 2017 · 4 months · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2022 · 14 months · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Jan 2023 · 2 months · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~May 2024 · 2 months · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Feb 2025 · 2 months · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

72 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Jul 2025 — Sep 2025 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  3. Jun 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE3

  4. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE3

▶ Show 67 earlier versions

  1. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Dec 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Nov 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE3

  5. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE3

  6. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  7. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  8. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  9. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

  10. Mar 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE3

  11. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE3

  12. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE3

  13. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE3

  14. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  15. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  16. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  17. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  18. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  19. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  20. Apr 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  21. Feb 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  22. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  23. Nov 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE3

  24. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

  25. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  26. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE3

  27. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

  28. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE3

  29. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  30. Jan 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE3

  31. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  32. Nov 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE3

  33. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  34. Sep 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE3

  35. Aug 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

  36. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE3

  37. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  38. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE3

  39. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  40. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  41. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE3

  42. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  43. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE3

  44. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE3

  45. Oct 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE3

  46. Sep 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE3

  47. Aug 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE3

  48. Jul 2019 — Aug 2019 [monthly]

    Active Not Recruiting PHASE3

  49. May 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE3

  50. Apr 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE3

  51. Mar 2019 — Apr 2019 [monthly]

    Active Not Recruiting PHASE3

  52. Feb 2019 — Mar 2019 [monthly]

    Active Not Recruiting PHASE3

  53. Jan 2019 — Feb 2019 [monthly]

    Active Not Recruiting PHASE3

  54. Dec 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE3

  55. Nov 2018 — Dec 2018 [monthly]

    Active Not Recruiting PHASE3

  56. Oct 2018 — Nov 2018 [monthly]

    Active Not Recruiting PHASE3

  57. Sep 2018 — Oct 2018 [monthly]

    Active Not Recruiting PHASE3

  58. Aug 2018 — Sep 2018 [monthly]

    Active Not Recruiting PHASE3

  59. Jul 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE3

  60. Jun 2018 — Jul 2018 [monthly]

    Active Not Recruiting PHASE3

  61. Dec 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  62. Nov 2017 — Dec 2017 [monthly]

    Active Not Recruiting PHASE3

  63. Oct 2017 — Nov 2017 [monthly]

    Active Not Recruiting PHASE3

  64. Jun 2017 — Oct 2017 [monthly]

    Active Not Recruiting PHASE3

  65. May 2017 — Jun 2017 [monthly]

    Active Not Recruiting PHASE3

  66. Feb 2017 — May 2017 [monthly]

    Active Not Recruiting PHASE3

  67. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE3

    First recorded

Dec 2008

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • NRG Oncology
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aberdeen, United States , Abington, United States , Adrian, United States , Akron, United States , Alamosa, United States , Albany, United States , Albuquerque, United States , Allentown, United States , Altamonte Springs, United States , Alton, United States and 706 more locations