Completed PHASE2 INTERVENTIONAL 2-arm NCT00894803

Study of the Combination Therapy of Rt-PA and Eptifibatide to Treat Acute Ischemic Stroke (CLEAR-ER)

The Combined Approach to Lysis Utilizing Eptifibatide and Rt-PA in Acute Ischemic Stroke-Enhanced Regimen (CLEAR-ER Stroke Trial)

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Conditions Brain Infarction Ischemic Stroke Stroke

Interventions Eptifibatide rt-PA

Updated 7 times since 2017 Last updated: Mar 26, 2014 Started: Jul 31, 2009 Primary completion: Oct 31, 2012 Completion: Dec 31, 2012

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT00894803, this PHASE2 trial focuses on Brain Infarction and Ischemic Stroke and remains completed. Sponsored by National Institute of Neurological Disorders and Stroke (NINDS), it has been updated 7 times since 2009, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2
Jan 2021 — Jul 2024 [monthly]

Completed PHASE2
Jun 2018 — Jan 2021 [monthly]

Completed PHASE2

▶ Show 2 earlier versions

Feb 2017 — Jun 2018 [monthly]

Completed PHASE2
Jan 2017 — Feb 2017 [monthly]

Completed PHASE2

First recorded

Jul 2009

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

National Institute of Neurological Disorders and Stroke (NINDS)
University of Cincinnati

Data source: University of Cincinnati

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Ann Arbor, United States , Asheville, United States , Bethesda, United States , Cincinnati, United States , Edgewood, United States , Florence, United States , Fort Thomas, United States , Los Angeles, United States , Morgantown, United States , New Brunswick, United States and 4 more locations