deltatrials
Completed PHASE1 INTERVENTIONAL NCT00994071

A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors

A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-Ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors

Sponsor: National Cancer Institute (NCI)

Conditions Astrocytoma Ependymoma Medulloblastoma PNET Pontine Glioma
Interventions ABT-888 Temozolomide
Updated 25 times since 2017 Last updated: Dec 6, 2019 Started: Sep 22, 2009 Completion: Mar 19, 2013
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Astrocytoma and Ependymoma and is currently completed. National Cancer Institute (NCI) leads this study, which shows 25 recorded versions since 2009 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Jan 2021 · 12 months · monthly snapshot~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 24 months · monthly snapshot

Change History

25 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE1

  4. Jan 2020 — Jan 2021 [monthly]

    Completed PHASE1

  5. Dec 2019 — Jan 2020 [monthly]

    Completed PHASE1

▶ Show 20 earlier versions

  1. Nov 2019 — Dec 2019 [monthly]

    Completed PHASE1

  2. Oct 2019 — Nov 2019 [monthly]

    Completed PHASE1

  3. Sep 2019 — Oct 2019 [monthly]

    Completed PHASE1

  4. Aug 2019 — Sep 2019 [monthly]

    Completed PHASE1

  5. Jul 2019 — Aug 2019 [monthly]

    Completed PHASE1

  6. Jun 2019 — Jul 2019 [monthly]

    Completed PHASE1

  7. May 2019 — Jun 2019 [monthly]

    Completed PHASE1

  8. Apr 2019 — May 2019 [monthly]

    Completed PHASE1

  9. Mar 2019 — Apr 2019 [monthly]

    Completed PHASE1

  10. Feb 2019 — Mar 2019 [monthly]

    Completed PHASE1

  11. Jan 2019 — Feb 2019 [monthly]

    Completed PHASE1

  12. Dec 2018 — Jan 2019 [monthly]

    Completed PHASE1

  13. Nov 2018 — Dec 2018 [monthly]

    Completed PHASE1

  14. Oct 2018 — Nov 2018 [monthly]

    Completed PHASE1

  15. Sep 2018 — Oct 2018 [monthly]

    Completed PHASE1

  16. Aug 2018 — Sep 2018 [monthly]

    Completed PHASE1

  17. Jul 2018 — Aug 2018 [monthly]

    Completed PHASE1

  18. Jun 2018 — Jul 2018 [monthly]

    Completed PHASE1

  19. Feb 2017 — Jun 2018 [monthly]

    Completed PHASE1

  20. Jan 2017 — Feb 2017 [monthly]

    Completed PHASE1

    First recorded

Sep 2009

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations