Completed PHASE4 INTERVENTIONAL 2-arm NCT01025466

Exelon Patch and Combination With Memantine Comparative Trial (EXPECT)

A Multicenter, Randomized, Open-label Study to Compare the Tolerability Between Rivastigmine Patch Monotherapy and Combination Therapy With Memantine in Patients With Alzheimer's Disease

Sponsor: Inha University Hospital

Conditions Alzheimer's Disease

Interventions Rivastigmine transdermal patch Rivastigmine transdermal patch (Exelon patch), memantine

Updated 6 times since 2017 Last updated: May 18, 2010 Started: Dec 31, 2008 Primary completion: Nov 30, 2009 Completion: Apr 30, 2010

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Alzheimer's Disease and is currently completed. Inha University Hospital leads this study, which shows 6 recorded versions since 2008 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Study Description(click to expand)

Recently, the rivastigmine patch demonstrated efficacy comparable to the highest doses of rivastigmine capsules, with markedly improved tolerability profile. We hypothesized that combination of memantine and rivastigmine patch will be safe and well tolerated and result in more clinical benefit in patients with AD in comparison with rivastigmine patch monotherapy, for the mechanisms of the drugs are different.

Status Flow

Change History

6 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE4
Sep 2024 — Sep 2025 [monthly]

Completed PHASE4
Jul 2024 — Sep 2024 [monthly]

Completed PHASE4
Jan 2021 — Jul 2024 [monthly]

Completed PHASE4
Jun 2018 — Jan 2021 [monthly]

Completed PHASE4

▶ Show 1 earlier version

Jan 2017 — Jun 2018 [monthly]

Completed PHASE4

First recorded

Dec 2008

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Inha University Hospital

Data source: Inha University Hospital

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Bucheon-si, South Korea , Busan, South Korea , Changwon, South Korea , Daegu, South Korea , Daejun, South Korea , Goyang, South Korea , Gwangju, South Korea , Iksan, South Korea , Incheon, South Korea , Pusan, South Korea and 3 more locations