Completed PHASE3 INTERVENTIONAL 3-arm NCT01099449

Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy

A Phase III Randomized, Placebo-Controlled, Double-Blind Study of Intravenous Calcium/Magnesium in Two Different Versions to Prevent Oxaliplatin-Induced Sensory Neurotoxicity

Sponsor: Alliance for Clinical Trials in Oncology

Conditions Chemotherapeutic Agent Toxicity Colorectal Cancer Neuropathy Neurotoxicity

Interventions calcium gluconate magnesium sulfate oxaliplatin placebo

Updated 10 times since 2017 Last updated: Nov 1, 2022 Started: Jun 30, 2010 Primary completion: Dec 31, 2012 Completion: Mar 31, 2013

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Chemotherapeutic Agent Toxicity and Colorectal Cancer and is currently completed. Alliance for Clinical Trials in Oncology leads this study, which shows 10 recorded versions since 2010 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

Change History

10 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2023 — Jul 2024 [monthly]

Completed PHASE3
Dec 2022 — Jan 2023 [monthly]

Completed PHASE3

▶ Show 5 earlier versions

Jan 2021 — Dec 2022 [monthly]

Completed PHASE3
Jun 2019 — Jan 2021 [monthly]

Completed PHASE3
Jun 2018 — Jun 2019 [monthly]

Completed PHASE3
Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Jun 2010

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Data source: Alliance for Clinical Trials in Oncology

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Adrian, United States , Akron, United States , Albany, United States , Allentown, United States , Anderson, United States , Ann Arbor, United States , Antigo, United States , Antioch, United States , Appleton, United States , Asheboro, United States and 265 more locations