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Completed PHASE2 INTERVENTIONAL 2-arm NCT01149083

Veliparib With or Without Carboplatin in Treating Patients With Stage III or IV Breast Cancer

Phase II Trial of Single Agent ABT-888 With Post-Progression Therapy of ABT-888 in Combination With Carboplatin in Patients With Stage IV BRCA-Associated Breast Cancer

Sponsor: National Cancer Institute (NCI)

Conditions Anatomic Stage III Breast Cancer AJCC v8 Anatomic Stage IV Breast Cancer AJCC v8 Locally Advanced Breast Carcinoma Metastatic Breast Carcinoma Unresectable Breast Carcinoma
Interventions Biopsy Biospecimen Collection Carboplatin Computed Tomography Magnetic Resonance Imaging Veliparib
Updated 42 times since 2017 Last updated: Aug 5, 2025 Started: Jun 30, 2010 Primary completion: Sep 30, 2024 Completion: Sep 30, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT01149083, this PHASE2 trial focuses on Anatomic Stage III Breast Cancer AJCC v8 and Anatomic Stage IV Breast Cancer AJCC v8 and remains completed. Sponsored by National Cancer Institute (NCI), it has been updated 42 times since 2010, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Oct 2017 · 4 months · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Feb 2018 · 3 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Jan 2019 · 5 months · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jul 2019 · 3 months · monthly snapshot~Jul 2019 – ~Nov 2019 · 4 months · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshot~Feb 2022 – ~Jul 2022 · 5 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~Aug 2023 · 7 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Dec 2023 · 2 months · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Mar 2024 · 2 months · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Sep 2025 · 9 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

42 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Dec 2024 — Sep 2025 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  3. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 37 earlier versions

  1. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Jan 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Oct 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE2

  6. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE2

  7. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE2

  8. Jan 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE2

  9. Sep 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE2

  10. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  11. Feb 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE2

  12. Sep 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE2

  13. Apr 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  14. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE2

  15. Feb 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE2

  16. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE2

  17. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  18. Aug 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

  19. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE2

  20. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE2

  21. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE2

  22. Mar 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE2

  23. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE2

  24. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE2

  25. Nov 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE2

  26. Jul 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE2

  27. Apr 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE2

  28. Mar 2019 — Apr 2019 [monthly]

    Active Not Recruiting PHASE2

  29. Jan 2019 — Mar 2019 [monthly]

    Active Not Recruiting PHASE2

  30. Aug 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE2

  31. Jun 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE2

  32. Feb 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE2

  33. Nov 2017 — Feb 2018 [monthly]

    Active Not Recruiting PHASE2

  34. Oct 2017 — Nov 2017 [monthly]

    Active Not Recruiting PHASE2

  35. Jun 2017 — Oct 2017 [monthly]

    Active Not Recruiting PHASE2

  36. Feb 2017 — Jun 2017 [monthly]

    Active Not Recruiting PHASE2

  37. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE2

    First recorded

Jun 2010

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aurora, United States , Baltimore, United States , Boston, United States , Chicago, United States , Duarte, United States , Hershey, United States , Houston, United States , Jacksonville, United States , Los Angeles, United States , New York, United States and 6 more locations