deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 4-arm NCT01154920

Paclitaxel, Carboplatin and Cetuximab (PCC) With Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma

Randomized Phase II Trial Contrasting Weekly Paclitaxel, Carboplatin and Cetuximab (PCC) With Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma

Sponsor: Dana-Farber Cancer Institute

Conditions Head and Neck Squamous Cell Carcinoma
Interventions Carboplatin Cetuximab Chemotherapy Cisplatin Docetaxel Fluorouracil Paclitaxel Radiotherapy (RT)
Updated 21 times since 2017 Last updated: Dec 11, 2025 Started: Jul 9, 2010 Primary completion: Dec 31, 2027 Completion: Dec 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Head and Neck Squamous Cell Carcinoma, this trial is ongoing. The trial is conducted by Dana-Farber Cancer Institute and has accumulated 21 data snapshots since 2010. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Oct 2017 · 8 months · monthly snapshot~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Jun 2019 · 12 months · monthly snapshot~Jun 2019 – ~Feb 2020 · 8 months · monthly snapshot~Feb 2020 – ~Jan 2021 · 11 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~May 2022 · 8 months · monthly snapshot~May 2022 – ~Nov 2022 · 6 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~May 2023 · 5 months · monthly snapshot~May 2023 – ~Sep 2023 · 4 months · monthly snapshot~Sep 2023 – ~Mar 2024 · 6 months · monthly snapshot~Mar 2024 – ~Jun 2024 · 3 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Jun 2025 · 5 months · monthly snapshot~Jun 2025 – ~Dec 2025 · 6 months · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – present · 6 months · monthly snapshot

Change History

21 versions recorded

  1. Jan 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Jun 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jan 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 16 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Mar 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2

  5. May 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE2

  6. Dec 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE2

  7. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

  8. May 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE2

  9. Sep 2021 — May 2022 [monthly]

    Active Not Recruiting PHASE2

  10. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  11. Feb 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  12. Jun 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE2

  13. Jun 2018 — Jun 2019 [monthly]

    Active Not Recruiting PHASE2

  14. Oct 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE2

  15. Feb 2017 — Oct 2017 [monthly]

    Active Not Recruiting PHASE2

  16. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE2

    First recorded

Jul 2010

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Dana-Farber Cancer Institute
  • M.D. Anderson Cancer Center
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations