deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT01249430

Azacitidine in Combination With Mitoxantrone, Etoposide Phosphate, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

A Phase 1 Study of Azacitidine in Combination With MEC (Mitoxantrone, Etoposide, Cytarabine) in Relapsed and Refractory Acute Myeloid Leukemia

Sponsor: National Cancer Institute (NCI)

Conditions Recurrent Adult Acute Myeloid Leukemia Refractory Acute Myeloid Leukemia
Interventions Azacitidine Cytarabine Etoposide Phosphate Laboratory Biomarker Analysis Mitoxantrone Hydrochloride Pharmacological Study
Updated 9 times since 2017 Last updated: Sep 20, 2017 Started: Jan 20, 2011 Primary completion: May 24, 2013 Completion: May 24, 2013
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT01249430, this PHASE1 trial focuses on Recurrent Adult Acute Myeloid Leukemia and Refractory Acute Myeloid Leukemia and remains completed. Sponsored by National Cancer Institute (NCI), it has been updated 9 times since 2011, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshotActive Not Recruiting~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshotActive Not Recruiting~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshotActive Not Recruiting~Aug 2017 – ~Oct 2017 · 2 months · monthly snapshotActive Not Recruiting~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshotCompleted~Jun 2018 – ~Jan 2021 · 31 months · monthly snapshotCompleted~Jan 2021 – ~Jul 2024 · 42 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – present · 23 months · monthly snapshotCompleted

Change History

9 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE1

  4. Jun 2018 — Jan 2021 [monthly]

    Completed PHASE1

  5. Oct 2017 — Jun 2018 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

▶ Show 4 earlier versions

  1. Aug 2017 — Oct 2017 [monthly]

    Active Not Recruiting PHASE1

  2. Jun 2017 — Aug 2017 [monthly]

    Active Not Recruiting PHASE1

  3. Feb 2017 — Jun 2017 [monthly]

    Active Not Recruiting PHASE1

  4. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE1

    First recorded

Jan 2011

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations