deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT01351896

Lenalidomide and Vaccine Therapy in Treating Patients With Early-Stage Asymptomatic Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Phase II Study of Lenalidomide to Repair Immune Synapse Response and Humoral Immunity in Early-Stage, Asymptomatic Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) With High-Risk Genomic Features

Sponsor: National Cancer Institute (NCI)

Conditions Ann Arbor Stage I Small Lymphocytic Lymphoma Ann Arbor Stage II Small Lymphocytic Lymphoma Chronic Lymphocytic Leukemia Chronic Lymphocytic Leukemia With Unmutated Immunoglobulin Heavy Chain Variable-Region Gene Small Lymphocytic Lymphoma Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable-Region Gene Stage 0 Chronic Lymphocytic Leukemia Stage I Chronic Lymphocytic Leukemia Stage II Chronic Lymphocytic Leukemia
Interventions Biospecimen Collection Bone Marrow Aspiration Bone Marrow Biopsy Computed Tomography Lenalidomide Pneumococcal Polyvalent Vaccine
Updated 34 times since 2017 Last updated: Nov 7, 2025 Started: Nov 2, 2011 Primary completion: Jul 8, 2024 Completion: May 6, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Ann Arbor Stage I Small Lymphocytic Lymphoma and Ann Arbor Stage II Small Lymphocytic Lymphoma and is currently ongoing. National Cancer Institute (NCI) leads this study, which shows 34 recorded versions since 2011 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2018 · 13 months · monthly snapshot~Jun 2018 – ~Nov 2018 · 5 months · monthly snapshot~Nov 2018 – ~Mar 2019 · 4 months · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Sep 2019 · 4 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Oct 2020 · 4 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshot~Feb 2022 – ~Jul 2022 · 5 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~Nov 2023 · 9 months · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~May 2024 · 5 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Jun 2025 · 9 months · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – present · 9 months · monthly snapshot

Change History

34 versions recorded

  1. Dec 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jun 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2024 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 29 earlier versions

  1. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  3. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Dec 2023 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE2

  6. Feb 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  7. Sep 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE2

  8. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  9. Feb 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE2

  10. Sep 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE2

  11. Apr 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  12. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE2

  13. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  14. Jun 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

  15. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE2

  16. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE2

  17. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE2

  18. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE2

  19. Dec 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE2

  20. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE2

  21. Oct 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE2

  22. Sep 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE2

  23. May 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE2

  24. Mar 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE2

  25. Nov 2018 — Mar 2019 [monthly]

    Active Not Recruiting PHASE2

  26. Jun 2018 — Nov 2018 [monthly]

    Active Not Recruiting PHASE2

  27. May 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE2

  28. Feb 2017 — May 2017 [monthly]

    Active Not Recruiting PHASE2

  29. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE2

    First recorded

Nov 2011

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations