deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 1-arm NCT01841723

Ibrutinib in Treating Patients With Relapsed Hairy Cell Leukemia

A Multicenter Phase 2 Study of the Bruton's Tyrosine Kinase Inhibitor PCI-32765 (Ibrutinib) for Treatment of Relapsed Hairy Cell Leukemia

Sponsor: National Cancer Institute (NCI)

Conditions Hairy Cell Leukemia Hairy Cell Leukemia Variant Recurrent Hairy Cell Leukemia Recurrent Hairy Cell Leukemia Variant
Interventions Biospecimen Collection Bone Marrow Aspiration Bone Marrow Biopsy Computed Tomography Ibrutinib Ultrasound Imaging
Updated 40 times since 2017 Last updated: Mar 12, 2026 Started: Apr 30, 2013 Primary completion: Dec 31, 2029 Completion: Dec 31, 2029
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT01841723, this PHASE2 trial focuses on Hairy Cell Leukemia and Hairy Cell Leukemia Variant and remains ongoing. Sponsored by National Cancer Institute (NCI), it has been updated 40 times since 2013, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Jun 2018 · 9 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Mar 2019 · 4 months · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~Jul 2020 · 4 months · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Sep 2021 · 6 months · monthly snapshot~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~May 2022 · 2 months · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Apr 2023 · 7 months · monthly snapshot~Apr 2023 – ~Nov 2023 · 7 months · monthly snapshot~Nov 2023 – ~May 2024 · 6 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Apr 2025 · 3 months · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Oct 2025 · 5 months · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – ~Mar 2026 · 28 days · monthly snapshot~Mar 2026 – present · 4 months · monthly snapshot

Change History

40 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Feb 2026 — Mar 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Jan 2026 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  4. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE2

  5. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 35 earlier versions

  1. May 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  2. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Jan 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  6. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  7. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  8. Nov 2023 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  9. Apr 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  10. Sep 2022 — Apr 2023 [monthly]

    Active Not Recruiting PHASE2

  11. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  12. May 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE2

  13. Mar 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE2

  14. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE2

  15. Sep 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  16. Mar 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  17. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  18. Sep 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  19. Jul 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  20. Mar 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  21. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  22. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  23. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  24. Sep 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  25. Jul 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  26. May 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  27. Mar 2019 — May 2019 [monthly]

    Recruiting PHASE2

  28. Nov 2018 — Mar 2019 [monthly]

    Recruiting PHASE2

  29. Sep 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  30. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  31. Sep 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  32. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE2

  33. Jun 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  34. Feb 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  35. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Apr 2013

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations